RCT = randomized controlled trial; MA = metaanalisis; sr = systematic review; DX = diagnosis; inc_ = incident; w_ = with; wo_ = without; pxs = patients; EX = exclusion; IN = inclusion; ↗️ = improve; ↘️ = worsen; ↑ = increase; ↓ = decrease; 𝙄𝙌𝘾 BS = 𝙄𝙉𝘼𝘼𝙌𝘾 ᴮᴼ brief scope = year (Y), journal (J), country (C) ➖ type of study (T) ➕ number of patients/sample (N) ➕ time (t) ➖ population (P), intervention (I), comparison (C), outcome (O, OC); p = primary; s = secondary; critILL = critically ill
1. A JC is an academic session where we go through a scientific article for 1 hour.
2. It takes place every Friday.
3. Its purpose is to understand and discuss relevant elements about the content taking interactive and pedagogic notes (highlighting, underlining and using other learning resources) about the content.
4. We generate further appraisal, identify the opportunities of learning and formulate some potential research questions.
5. We write down the key-points of every session and publish them on our website
6. The article for the next session is posted one week in advance the must-read JC channel of our DISCORD server.
2018 CID - Renal Dosing of Antibiotics Are We Jumping the Gun (Crass) [r].pdf
Codified by ABFL
Glossary:
🪲 = microorganisms;
♾ = renal;
ATB = antibiotics;
Ccr = creatinine clearance;
CKD = chronic kidney disease;
1. EVIDENCE
- ATB dose adjustments applies for stable CKD
- May not apply to late late-phase trials and practice.
- Ceftolozane/tazobactam, ceftazidime/avibactam, and telavancin ➩ all have precautionary
statements for ↓ clinical response (Ccr 30-50) ➩ no need to adjust doses
2. ATB elimination is mostly relevant in acute cases during the 1st 48h
3. Toxicity + efficacy should be considered in every ATB
4. FDA ➩ inferior EFFICACY in moderate ♾ impairment.
5. GOAL ➩ Keep efficacy with the ↓ toxicity possible.
6. CKD studies available in CKD are small, early phase of healthy
7. “Antibiotics do not fit cleanly into this paradigm due to overwhelmingly episodic, rather than
chronic, use.” Crass 2018
⏳ TIME MANAGEMENT.
01:22:41
Round: 5 01:11:57 Comments
Round: 4 27:19:13 JC main points
Round: 3 32:18:27 JC intro
Round: 2 12:30:77 Codification discussion
Round: 1 09:21:62 Past JC
Friday, January 10 , 2025 at 18h30 at BO - 23h30 at BE
ABFL, CORA, AMA, MAAT, DFM, HIBN, AAQC
Codified by MAAT
Glossary: 🫁 = lungs; 🤔 = analysis; ⏎ = return; ARDS = acute respiratory distress syndrome; BLUE = The American Journal of Respiratory and Critical Care Medicine.
1. 𝙄𝙌𝘾 BS ➩ Y, J, C ➖ T ➕ N ➕ t ➖ P I C O:
2. 𝙄𝙌𝘾 BS 🟰 2024, BLUE, FR ➖ retro_prag_🤔 - cohort ➕ 41pxs ➕ 8y (2014 - 2022) ➖ P I C O:
- P: adults + ECCO2R
- I: Vt ≤3mL/Kg (ultra-protective vent)
- C: NA
- O: p_OC = feasibiliy (proportion of sessions) ➖ s_OC = efficacy + safety + others (adverse
events, SS90)
3. EVIDENCE: - …
⏳ TIME MANAGEMENT.
01:13:20
Round: 4 10:34:78 Comments
Round: 3 51:30:02 ART ultra-low volume ventilation
Round: 2 05:36:00 Select ART
Round: 1 05:39:31 Past JC
Friday, January 3 , 2025 at 18h30 at BO - 23h30 at BE
ABFL, CORA, AMA, MAAT, DFM, HIBN, AAQC
⏳ TIME MANAGEMENT.
01:27:38
Round: 8 00:01:30 The end
Round: 7 06:31:64 Wrap-up
Round: 6 12:09:86 Images + keypoints
Round: 5 37:44:75 ART 1 original
Round: 4 21:01:46 ART 1 prequel
Round: 3 04:19:04 Selection
Round: 2 02:13:15 Past JCRound: 1 03:37:75 Past JC
⏳ TIME MANAGEMENT.
01:18:15
Round: 5 06:07:41 Figures
Round: 4 20:28:69 Content + wu
Round: 3 33:11:79 Article UO
Round: 2 06:06:67 Article choice
Round: 1 12:21:18 Past JC
⏳ TIME MANAGEMENT.
01:28:32
Round: 4 06:18:93 Comments
Round: 3 01:07:40 ART
Round: 2 09:17:00 ART selection
Round: 1 05:16:43 Past JC
2024 JACC - From ST-Segment Elevation MI to Occlusion MI (McLaren) [r].pdf
Codified by AMA
Glossary:
ACC = American College of Cardiology, ACO = acute coronary occlusion, INT = interpretation, MI = myocardial infarction, OMI = occlusion MI, STEMI = ST-segment elevation MI.
1. Q-wave/non-Q wave ➩ STEMI 🆚 non-STEMI ➩ OMI
2. 25% from non-STEMI have ACO ➩ limitation
3. OMI rises based on ✔ or ✖ of ACO
4. OMI paradigm = advanced ECG (INT aided by AI ➕ ECHO ➕ imaging ➕ refractory
ischemia (clinical signs).
5. Benefits of OMI paradigm = opportunity to transform ER 🫀 +↗️pxs care.
6. Thomas Kuhn introduced the concept of PARADIGM SHIFT
7. To guide problem solving activities ➩ definition + methods
8. 2021 CIRCULATION ➩ although the dichotomuos classification (STEMI/non-STEMI), IT IS
LIKELY that the main pathophysiological event is ACUTE VESSEL OCCLUSION
(determining prognosis + natural history).
9. ACC consensus (2022) ➩ STEMI criteria (12-lead ECG) misses A SIGNIFICANT MINORITY
of pxs w_ACO.
10. Alencar, 3 studies ➩ STEMI criteria for ACO = sensibility 44%
⏳ TIME MANAGEMENT.
01:09:58
Round: 5 01:33:50 Comments
Round: 4 13:41:71 wrap-up
Round: 3 34:16:12 ART
Round: 2 08:23:64 ART selection
Round: 1 12:03:40 Past JC
Friday, February 28 , 2025 at 18h30 at BO - 23h30 at BE
AMA, MAAT, GMC, MACR, HIBN, AAQC
Codified by AMA
Glossary:
C19 = COVID-19; DIS = discharge; HRQoL = health-related quality of life; ICU-VR = intensive care unit virtual reality; MH = mental health; PICS-F = post-intensive care syndrome-family; PTS = post-traumatisc stress; rel = relatives; SOC = standard of care; TECH = technology
1. 𝙄𝙌𝘾 BS ➩ Y, J, C ➖ T ➕ N ➕ t ➖ P I C O:
2. 𝙄𝙌𝘾 BS 🟰 2025, CC, NL ➖ mc_px-cluste_RCT ➕ 189 rel ➕ 1y3m = Jan 2021 - Apr 2022 (+6m after DIS) ➖ P I C O:
- P: rel (adult pxs)
- I: SOC + ICU-VR (100 rel of 81 pxs)
- C: SOC (89 rel of 80 pxs)
- O: symptoms of MH distress (DIFF ↔ prevalence + severity of PTSD + anxiety +
depression). sOC = understanding of ICU environment & procedure ➕ perspectives
toward ICU-VR
3. EVIDENCE:
- Mental health challenges in CI pxs’ rel: PTS + anxiety + depression
- MH sequealae
4. METHODS.
- IN ➠ rel 1st or 2nd degree ➕ ICU stay ≥72h ➕ multiple rel could participate
- EX ➠ language barrier ➕ no TECH ➕ no formal 🏡 address.
- RANDOM ➠ all relatives from one px were assigned to the SAME GROUP (↓ r of cross-
contamination) ➩ STRATIFIED in centers ➕ ability to visit the hospital (C19)
- INTERV ➠ 48h after admission (time to approach the rel) ➕ rel could share the study-
relation info
* 14 min
* Voice-over pre-recorded
* Mock patient lying
6. RESULTS
- Baseline, discharge, 1, 3, 6 months ➩ study periods (questionnaire)
- NO DIFF in pOC
- DIFF on understanding of ICU treatment ➕ perception/perspective on ICU-VR ➩ BOTH ↗
7. RATIONALE
* A more tailored, multifaceted approach, incorporating a combination of interventions like ICU-VR at different stages of the ICU experience may prove more effective.
8. LIMITATIONS
- Not blinded to rel & investigators (blinded to researcher)
⏳ TIME MANAGEMENT.
01:25:47
Round: 7 07:25:35 Comments
Round: 6 11:46:41 Results
Round: 5 30:00:94 Methods
Round: 4 16:27:26 INTRO
Round: 3 11:42:31 JC, abstract
Round: 2 03:16:61 ART selection
Round: 1 05:08:43 past JC
Friday, February 21 , 2025 at 18h30 at BO - 23h30 at BE
AMA, MAAT, DFM, MACR, HIBN, AAQC